Why Many People Can’t Lose Weight

If you find losing weight to be difficult, you’re not alone. But your leptin receptors might be.

Leptin is an important hormone, secreted by fat cells, that helps control your appetite and your metabolism.

If everything is working normally, it works like this:

The more fat tissue you have, the more circulating leptin you will have; the more leptin you have, the less hungry you’ll be, and the faster you’ll burn up energy.

So losing weight should be easy, right? Because if you have excess weight, the leptin should be telling your brain to stop eating and to speed up your metabolism.

But it appears that many people carrying excess fat have developed something called leptin resistance. Meaning, all those fat cells may be sending out lots of leptin, but your brain isn’t getting the message.

However, it’s important to realize that our understanding of leptin is still limited.

Leptin is a relatively new discovery (it was named in 1994). So while there have been a number studies done (most on rats and mice), we’re still figuring this hormone out.

For instance, in one study, rats fed a 60% fructose diet for six months became leptin resistant. This means that giving them extra leptin did not slow down their eating habits. But, in another study, a slightly more moderate consumption of fructose or glucose appeared to be protective against leptin resistance in rats also fed a high-fat diet (30% fat).

So while there are definitely some actions you can take to help reduce leptin resistance, it’s important to realize that a lot of the ideas out there are little more than best guesses. They may be very good guesses, but I wouldn’t base your whole eating plan on them.

So what should you do?

Firstly, don’t lose hope. Leptin resistance does show signs of being reversible. And, while the research is still not complete, there are several sensible things you can do that should help.

1 Avoid overeating, but don’t go on a calorie-restrictive diet. 

While overeating can temporarily boost leptin production, if it goes on for too long, it can lead to leptin resistance.

At the same time, suddenly restricting caloric intake can reduce leptin production. So going on calorie reduction diets can actually reduce your circulating leptin, telling your brain to slow down your metabolism and increase your hunger, even if you aren’t leptin resistant.

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